Effects of TMEM206 on the malignant behavior of HepG2 human hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is the most common cancer of digestive system. Recently, transmembrane proteins (TMEMs) have been extensively studied in different types malignant tumors. However, influence TMEM206 hepatocellular unclear. The UALCAN database was used to investigate expression mRNA liver tissues and Human Protein Atlas (THPA) study HCC tissues. measured normal HL-7702 cells HepG2, SMMC-7721, Bel-7402 cells. Next, a lentivirus knockdown HepG2 Furthermore, after verifying knockdown, we effect downregulation on behavior PI3K/AKT pathway. highly expressed ( p < 0.001). Downregulation significantly inhibited proliferation, migration invasion promoted apoptosis P-PI3K P-AKT. can affect HCC. And pathway affected. This provides new ideas for treatment